反应详情

温度

25 °C

A solution of 9.7 g of 3-phenoxyacetophenone and 12.2 g of ethyl chloroacetate in 30 ml of ethyl ether was vigorously stirred, and 8.8 g of sodium ethoxide was gradually added thereto in a nitrogen stream at 5°-6° C. over a period of 1 hour. After stirring at 6° C. for 1 hour, at 25° C. for 1 hour and at refluxing temperature for 1 hour, the mixture was cooled and charged with ether and water, thereby effecting ether extraction. The ether layer was washed with water and then dried over anhydrous sodium sulfate. The ether was removed by distillation under reduced pressure. The residue was dissolved in 150 ml of butyl ether, and the solution was charged with 12 g of aluminum chloride and refluxed with stirring at 80° C. for 5 hours. After cooling, the mixture was charged with dilute hydrochloric acid and, after stirring for 20 minutes, the butyl ether layer was separated, and the aqueous layer was extracted with butyl ether. The extract was combined with the separated butyl ether layer, and the combined layer was successively washed with water, aqueous sodium bicarbonate solution and water, and then dried over anhydrous magnesium sulfate. The butyl ether was removed by distillation under reduced pressure, and the residue was purified by silica gel column chromatography to obtain 4.5 g of ethyl 2-hydroxy-3-(3-phenoxyphenyl)-3-butenoate. The yield was 46%.

1. temperatureat refluxing temperature for 1 hour
2. temperaturethe mixture was cooled
3. extractioneffecting ether extraction
4. washThe ether layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customThe ether was removed by distillation under reduced pressure
7. dissolutionThe residue was dissolved in 150 ml of butyl ether
8. additionthe solution was charged with 12 g of aluminum chloride
9. temperaturerefluxed
10. stirringwith stirring at 80° C. for 5 hours
11. temperatureAfter cooling
12. additionthe mixture was charged with dilute hydrochloric acid
13. stirringafter stirring for 20 minutes
14. customthe butyl ether layer was separated
15. extractionthe aqueous layer was extracted with butyl ether
16. washthe combined layer was successively washed with water, aqueous sodium bicarbonate solution and water
17. dry with materialdried over anhydrous magnesium sulfate
18. customThe butyl ether was removed by distillation under reduced pressure
19. customthe residue was purified by silica gel column chromatography