N-bromobutanimide → HCID 66911302, compound

HRID 44180Notes

Reaction equation

HRID 44180 reaction equation
[F:1][C:2]1[CH:11]2[CH:6]([CH2:7][CH2:8][C:9](=[O:12])[NH:10]2)[CH:5]=[CH:4][CH:3]=1.C1C(=O)N([Br:20])C(=O)C1>>[Br:20][C:4]1[CH:3]=[C:2]([F:1])[CH:11]2[CH:6]([CH2:7][CH2:8][C:9](=[O:12])[NH:10]2)[CH:5]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 67152386HCID 67152386, compound

Product 1

HCID 66911302HCID 66911302, compound

Procedure

This intermediate was obtained according to general procedure I from 8-fluoro-3,4,4a,8a-tetrahydro-1H-quinolin-2-one (515 mg, 3.12 mmol) and NBS (583 mg, 3.27 mmol) after flash chromatography on silica gel (hexanes/ethyl acetate, 5/1, Rf=0.32) as white solid (647 mg, 2.65 mmol, 85%).

Workup

  1. customThis intermediate was obtained

Sources & evidence

ORD record
ord-79590afd778b4ec1a7eb84ad4b54b6a5
Source dataset
uspto-grants-2013_09
Patent number
US08541404B2

Reaction notes

Loading…