反应详情

A mixture of 2-isopropyl-4-methylpent-4-enoic acid (1.0g), alpha-cyano-3-phenoxybenzyl bromide (1.9g) and potassium carbonate (1.0g) in anhydrous acetone (40ml) was stirred at room temperature for 4 hours. Water was added to the reaction mixture and the product extracted with ether, the ethereal extracts washed with water (X2) and dried over magnesium sulphate. Evaporation of the solvent gave a crude product which was purified by chromatography on silica gel using 3% acetone in 60°-80° C. petroleum ether as eluent to give the desired ester. R.I. nD20 1.5343.

1. extractionthe product extracted with ether
2. washthe ethereal extracts washed with water (X2)
3. dry with materialdried over magnesium sulphate
4. customEvaporation of the solvent
5. customgave a crude product which
6. customwas purified by chromatography on silica gel using 3% acetone in 60°-80° C. petroleum ether as eluent