Ethyl 2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate → 2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid

HRID 441845Notes

Reaction equation

HRID 441845 reaction equation
[CH3:1][C:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:24](=[O:34])[C:25]3[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:26]=3[O:32][CH3:33])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)([CH3:8])[C:3]([O:5]CC)=[O:4]>[OH-].[K+].O1CCOCC1>[CH3:8][C:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:24](=[O:34])[C:25]3[CH:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:26]=3[O:32][CH3:33])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 1

HCID 21418525Ethyl 2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate

Product 1

HCID 214185292-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acidYield 72%

Reagents, catalysts & solvents 2

HCID 14797Potassium HydroxideSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid was prepared by alkaline hydrolysis of ethyl 2-methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate in 1 N potassium hydroxide and dioxane (1:5) at room temperature. Yield: 72% of theory; m.p. 104° C.

Sources & evidence

ORD record
ord-658927f21e174baaad42c225799e8062
Source dataset
uspto-grants-1977_08
Patent number
US04042711

Reaction notes

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