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HRID441845

反应详情

EQUATION

反应方程式

HRID 441845 的结构方程式

REACTANTS

反应物

1
反应SMILES：CCOC(=O)C(C)(C)Oc1ccc(-c2ccc(CNC(=O)c3cc(Cl)ccc3OC)cc2)cc1
HCID21418525

未命名化合物

PRODUCTS

产物

1
反应SMILES：COc1ccc(Cl)cc1C(=O)NCc1ccc(-c2ccc(OC(C)(C)C(=O)O)cc2)cc1
HCID21418529

未命名化合物

收率 72%

AUXILIARIES

试剂、催化剂与溶剂

2
反应SMILES：[K+].[OH-]
溶剂HCID14797

Potassium hydroxide

HKO

反应SMILES：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid was prepared by alkaline hydrolysis of ethyl 2-methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate in 1 N potassium hydroxide and dioxane (1:5) at room temperature. Yield: 72% of theory; m.p. 104° C.