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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 441845Generated: October 29, 2026

Ethyl 2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate → 2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid

https://huagongshe.com/reaction/441845

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-Methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionateHCID 21418525—
SolventPotassium HydroxideHCID 14797—
Solvent1,4-DioxaneHCID 31275—
Product2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acidHCID 2141852972%

Reaction Steps

2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'oxy}-propionic acid was prepared by alkaline hydrolysis of ethyl 2-methyl-2-{4-[2-methoxy-5-chloro-benzamido-methyl]-biphenyl-4'-oxy}-propionate in 1 N potassium hydroxide and dioxane (1:5) at room temperature. Yield: 72% of theory; m.p. 104° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04042711
Source datasetuspto-grants-1977_08
ORD IDord-658927f21e174baaad42c225799e8062
Source noteuspto-grants-1977_08