Hydrochloric Acid → HCID 12886936, compound

HRID 441848Notes

Reaction equation

HRID 441848 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[C:5](=[N:20][NH:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=1)[C:6](=[CH:13]N1CCOCC1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].Cl>O1CCOCC1>[CH2:1]([O:3][C:4]([C:5]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:13][N:21]([C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=2)[N:20]=1)=[O:29])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86735009HCID 86735009, compound

Product 1

HCID 12886936HCID 12886936, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

27.6 g. of 2-(4-methylphenylhydrazono)-3-morpholinomethylene-3-phenylpropionic acid ethyl ester are treated with 260 ml. of dioxane and 80 ml. of 2N hydrochloric acid and are heated under reflux for 45 minutes. The reaction is allowed to cool and then is concentrated in vacuum, the residue being taken up in chloroform. The chloroform phase is washed with water and concentrated in vacuum. The residue is treated with petroleum ether. 17.1 g. of 4-phenyl-1-(4-tolyl)-3-pyrazolecarboxylic acid ethyl ester, melting point 115°-117° C., is obtained.

Workup

  1. temperatureunder reflux for 45 minutes
  2. temperatureto cool
  3. concentrationis concentrated in vacuum
  4. washThe chloroform phase is washed with water
  5. concentrationconcentrated in vacuum
  6. additionThe residue is treated with petroleum ether

Sources & evidence

ORD record
ord-3e44f4b85c5744288cff98ee43d46e28
Source dataset
uspto-grants-1977_08
Patent number
US04042706

Reaction notes

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