Hydrochloric Acid → HCID 21418271, compound

HRID 441853Notes

Reaction equation

HRID 441853 reaction equation
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([O:23]CC)=[O:22].C(O)C.[OH-].[Na+].Cl>O>[Cl:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([OH:23])=[O:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 53996186HCID 53996186, compound

Product 1

HCID 21418271HCID 21418271, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.8 g of ethyl 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetate, 13 ml of ethanol and 1.0 g of sodium hydroxide are heated in 13 ml of water for 1 hour for boiling. The pH is reduced to 10 and the alcohol is distilled off in vacuo. The aqueous solution is shaken up with ether and purified with active charcoal. Acidification is carried out with dilute hydrochloric acid and with a yield of 83% 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetic acid is obtained; F 179.5°-181°.

Workup

  1. distillationthe alcohol is distilled off in vacuo
  2. custompurified with active charcoal

Sources & evidence

ORD record
ord-622f7374d11443d38871e2dd3f25456b
Source dataset
uspto-grants-1977_08
Patent number
US04042702

Reaction notes

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