Hydrochloric Acid → 5-(Piperidin-1-yl)pentanoic acid hydrochloride

HRID 441876Notes

Reaction equation

HRID 441876 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:15]>O>[ClH:15].[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20361138HCID 20361138, compound

Product 1

HCID 545927615-(Piperidin-1-yl)pentanoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

23.5 g. (0.117 mole) of methyl δ-piperidinovalerate was dissolved in a combination of 125 ml. of concentrated hydrochloric acid and 125 ml. of water and refluxed with stirring for 16 hours. The excess water was removed using reduced pressure (water aspirator) to give a semi-solid residue which was triturated with acetone, filtered and dried. 21.0 g. (79%) of colorless crystals of δ-piperidinovaleric acid hydrochloride was obtained with a m.p. of 202°-204° C.

Workup

  1. customThe excess water was removed
  2. customto give a semi-solid residue which
  3. customwas triturated with acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-d1191084f12c4bb0b47d3611a5065c8f
Source dataset
uspto-grants-1977_08
Patent number
US04042694

Reaction notes

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