HRID441885

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID14855682

4-(Pyrrolidin-1-yl)butanoic acid--hydrogen chloride (1/1)

C8H16ClNO2

结构：CCCCCCCCCCCCC(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CCc2ccccc2)CC1

HCID21418116

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCC(C)c1cc(OC(=O)CCCN2CCCC2)c2c(c1)OC(C)(C)C1=C2CN(CCc2ccccc2)CC1.Cl

HCID21418149

未命名化合物

PROCEDURE

实验过程

5,5-Dimethyl-10-hydroxy-2-phenethyl-8-(2-tetradecyl)-1,2,3,4-tetrahydro-5H-[ 1]benzopyrano[3,4-d]pyridine, γ-pyrrolidinobutyric acid hydrochloride and dicyclohexylcarbodiimide are reacted in equimolar amounts according to Example 1 to produce the desired product.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dd22514682b94b439e09aa456bd562b5
来源数据集: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04042694
来源说明: uspto-grants-1977_08

反应 SMILES

[CH3:1][C:2]1([CH3:39])[C:26]2[CH2:27][CH2:28][N:29]([CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:30][C:25]=2[C:5]2[C:6]([OH:24])=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:11])=[CH:9][C:4]=2[O:3]1.[ClH:40].[N:41]1([CH2:46][CH2:47][CH2:48][C:49](O)=[O:50])[CH2:45][CH2:44][CH2:43][CH2:42]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:40].[CH3:39][C:2]1([CH3:1])[C:26]2[CH2:27][CH2:28][N:29]([CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:30][C:25]=2[C:5]2[C:6]([O:24][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][N:41]3[CH2:45][CH2:44][CH2:43][CH2:42]3)=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:11])=[CH:9][C:4]=2[O:3]1