Dicyclohexylcarbodiimide → 2-Cinnamyl-8-cyclopropylmethyl-5,5-di(1-propyl)-10-[4-(pyrrolidino)butyryloxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Dicyclohexylcarbodiimide	HCID 10868	—
Reactant	4-(Pyrrolidin-1-yl)butanoic acid hydrochloride	HCID 14855682	—
Reactant	2-Cinnamyl-8-cyclopropylmethyl-5,5-di(1-propyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine	HCID 54479289	—
Product	2-Cinnamyl-8-cyclopropylmethyl-5,5-di(1-propyl)-10-[4-(pyrrolidino)butyryloxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride	HCID 68118892	—

Reaction Steps

2-Cinnamyl-8-cyclopropylmethyl-5,5-di(1-propyl)-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine, γ-pyrrolidinobutyric acid hydrochloride and dicyclohexyl-carbodiimide are reacted in equimolar amounts according to Example 1 to form the desired product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04042694
Source dataset	uspto-grants-1977_08
ORD ID	ord-7678024ad67046cd9c9f3b15458cba1f
Source note	uspto-grants-1977_08