反应详情

0.57 g. of ethyl cyanoacetate and 0.38 g. of thiourea are heated under reflux in 3 ml. of methanol in the presence of 1.17 g. of the sodium salt of 2-hydroxypyridine. After completion of reaction, 4 ml. of water is added, and the solution is neutralized with 0.58 ml. of acetic acid, to deposit the desired monohydrate crystals are obtained. Yield: 82 percent. The ultraviolet absorption spectrum agrees closely with the literature values.

1. temperatureunder reflux in 3 ml
2. customAfter completion of reaction, 4 ml
3. customare obtained
4. customThe ultraviolet absorption spectrum