反应详情

To a solution of 11.0 parts of diethylphosphite in 175 parts of methylene chloride and 4 drops of triethyl amine was added 10.0 parts of ethoxycarbonyl isocyanate. The solution was refluxed for 3 hours. Removing the solvent under reduced pressure left 18.5 parts of colorless oil which partially crystallized. The crystals were washed with cyclohexane to give 7.3 parts of ethyl N-(diethylphosphonocarbonyl)carbamate, m.p. 57°-64°, The proton nmr spectrum was consistent with this structure. (δNH = 10.0 ppm)

1. temperatureThe solution was refluxed for 3 hours
2. customRemoving the solvent under reduced pressure
3. waitleft 18.5 parts of colorless oil which
4. custompartially crystallized
5. washThe crystals were washed with cyclohexane