Phosphorus pentachloride → 8-Quinolinesulfonyl chloride

HRID 441930Notes

Reaction equation

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[S:11]([OH:14])(=O)=[O:12])[CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[S:11]([Cl:16])(=[O:14])=[O:12])[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 24819Phosphorus pentachloride

HCID 665618-Quinolinesulfonic acid

Product 1

HCID 292208-Quinolinesulfonyl chloride

Conditions

Temperature: 140 °C

Procedure

Equal quantities by weight of 8-quinolinesulfonic acid and phosphorous pentachloride were ground together in a mortar. This mixture was then refluxed at approximately 140° C. for 3 hours after which work-up of the reaction mixture gave 8-quinolinesulfonyl chloride.

Sources & evidence

ORD record: ord-987237a46b904b57ac722dd7691348d5
Source dataset: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04043922

Reaction notes

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