1-Bromo-3-chloropropane → HCID 21416325, compound

Participants

Reaction Steps

144 grams of N-(2-methoxyethyl)-piperazine and 157.5 grams of 3-bromo-1-chloropropane were dissolved in 500 milliliters of ethanol and refluxed for 2 hours. The ethanol was evaporated, the residue dissolved in water, the aqueous solution made alkaline with sodium hydroxide solution, the solution extracted with ether, the ether solution separated, washed with water, dried and evaporated, 110 grams of 4-(2-methoxyethyl)-1-(3-chloropropyl)-piperazine was thus obtained as a yellow oil.

Provenance & Evidence