1-Bromo-3-chloropropane → HCID 21416325, compound

HRID 442046Notes

Reaction equation

HRID 442046 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1.Br[CH2:12][CH2:13][CH2:14][Cl:15]>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH2:14][Cl:15])[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 27346381-(2-Methoxyethyl)piperazine

Product 1

HCID 21416325HCID 21416325, compoundYield 49.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

144 grams of N-(2-methoxyethyl)-piperazine and 157.5 grams of 3-bromo-1-chloropropane were dissolved in 500 milliliters of ethanol and refluxed for 2 hours. The ethanol was evaporated, the residue dissolved in water, the aqueous solution made alkaline with sodium hydroxide solution, the solution extracted with ether, the ether solution separated, washed with water, dried and evaporated, 110 grams of 4-(2-methoxyethyl)-1-(3-chloropropyl)-piperazine was thus obtained as a yellow oil.

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe ethanol was evaporated
  3. dissolutionthe residue dissolved in water
  4. extractionthe solution extracted with ether
  5. customthe ether solution separated
  6. washwashed with water
  7. customdried
  8. customevaporated

Sources & evidence

ORD record
ord-c8f7a27a3fc24ff6ac62df906431daab
Source dataset
uspto-grants-1977_08
Patent number
US04044024

Reaction notes

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