Hydrogen Peroxide → HCID 178481740, compound

HRID 442114Notes

Reaction equation

HRID 442114 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH3:19])[N:9]=[C:10]([C:11]3[O:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=3)[C:3]=12.[OH:20]O>C(O)(=O)C>[NH2:1][C:2]1[N+:7]([O-:20])=[CH:6][N:5]=[C:4]2[N:8]([CH3:19])[N:9]=[C:10]([C:11]3[O:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=3)[C:3]=12

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 214166481-Methyl-3-(5-nitrofuran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 178481740HCID 178481740, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 2.0 grams of 4-amino-1-methyl-3-(5-nitro-2-furyl)-1H-pyrazolo [3,4-d]pyrimidine dissolved in 100 millilitres of glacial acetic acid and 10 millilitres of 30% w/v hydrogen peroxide solution (100 volumes) was allowed to stand at room temperature for 3 days. The reaction mixture was evaporated to dryness and the solid product was collected, washed with acetic acid and dried. Recrystallisation from water gave 4-amino-1-methyl-3-(5-nitro-2-furyl)-1H-pyrazolo [3,4-d]pyrimidin-5-oxide, having melting point 285° C.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customthe solid product was collected
  3. washwashed with acetic acid
  4. customdried
  5. customRecrystallisation from water

Sources & evidence

ORD record
ord-d3dd335b98f040eb9cbcb3f5e22b0edc
Source dataset
uspto-grants-1977_08
Patent number
US04044130

Reaction notes

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