Ethanol → HCID 13673470, compound

HRID 442157Notes

Reaction equation

HRID 442157 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[Cl:33])[CH2:5][O:6][C:7]([C:9]1[CH:10]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N+:27]([O-:29])=[O:28])[C:11]([C:17]([O:19]C)=O)=C(C)[NH:13][C:14]=1[CH3:15])=[O:8].[CH2:34]([OH:36])C.[CH2:37]([OH:40])[CH2:38]C>>[CH3:34][O:36][C:37]([CH2:38][C:17](/[CH:11]=[CH:10]/[C:21]1[C:22]([N+:27]([O-:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])=[O:40].[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[Cl:33])[CH2:5][O:6][C:7](=[O:8])/[CH:9]=[C:14](\[NH2:13])/[CH3:15]

Participants

5

Reactant 3

HCID 702EthanolHCID 10311-PropanolHCID 68122457HCID 68122457, compound

Product 2

HCID 13673470HCID 13673470, compoundHCID 70596764HCID 70596764, compound

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 3,4-dichlorobenzyl ester in 120 ml of n-propanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dichlorobenzyl ester of melting point 137° C (from ethanol).

Sources & evidence

ORD record
ord-6a1974af24f74f40a581502c26282000
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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