Ethanol → HCID 70595485, compound

HRID 442168Notes

Reaction equation

HRID 442168 reaction equation
[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][O:7][C:8]([C:10]2C(C3C=CC=C([N+]([O-])=O)C=3)C(C(OC(C)C)=O)=C(C)[NH:14][C:15]=2[CH3:16])=[O:9])=[CH:4][CH:3]=1.C(O)C>C(O)(C)C>[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 68121602HCID 68121602, compound

Product 1

HCID 70595485HCID 70595485, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 4-chlorobenzyl ester in 120 ml of isopropanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-chlorobenzyl ester of melting point 137° C (from ethanol).

Sources & evidence

ORD record
ord-6c3d2829abd54ea4b56eb463285fb486
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

Loading…