Ethanol → HCID 86735019, compound

HRID 442173Notes

Reaction equation

HRID 442173 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:33]=[CH:34][C:35]=1[O:36][CH3:37])[CH2:6][O:7][C:8]([C:10]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC(C)C)=O)=C(C)[NH:14][C:15]=1[CH3:16])=[O:9].C(O)C>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:33]=[CH:34][C:35]=1[O:36][CH3:37])[CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16]

Participants

4

Reactant 2

HCID 702EthanolHCID 68121827HCID 68121827, compound

Product 1

HCID 86735019HCID 86735019, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 3,4-dimethoxybenzyl ester in 120 ml of isopropanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dimethoxybenzyl ester of melting point 154° C (from ethanol).

Sources & evidence

ORD record
ord-cd353d4f1a154701b713f3435640463a
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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