HCID 86735024, compound → HCID 86735023, compound

HRID 442175Notes

Reaction equation

HRID 442175 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:10][C:11]([C:13]2C(C3C=CC=C([N+]([O-])=O)C3=C=O)C(OCCOC)=C(C)[NH:17][C:18]=2[CH3:19])=[O:12])[CH3:9])=[CH:4][CH:3]=1>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([O:10][C:11](=[O:12])/[CH:13]=[C:18](\[NH2:17])/[CH3:19])[CH3:9])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 86735024HCID 86735024, compound

Product 1

HCID 86735023HCID 86735023, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid 2-methoxyethyl ester and 75 mmols of β-aminocrotonic acid 1-(4-chlorophenyl)-ethyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-(2-methoxyethyloxy)-carbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 1-(4-chlorophenyl)-ethyl ester of melting point 106° C (from ethanol).

Sources & evidence

ORD record
ord-946e301f827f4a718c5e3f5192687d04
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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