HCID 68122777, compound → HCID 86735021, compound

HRID 442177Notes

Reaction equation

HRID 442177 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[CH2:4][O:5][C:6]([C:8]1C(C2C=CC=CC=2Cl)C(C(OCC)=O)=C(C)[NH:12][C:13]=1[CH3:14])=[O:7]>C(O)C>[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[CH2:4][O:5][C:6](=[O:7])/[CH:8]=[C:13](\[NH2:12])/[CH3:14]

Participants

3

Reactant 1

HCID 68122777HCID 68122777, compound

Product 1

HCID 86735021HCID 86735021, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-chlorobenzylideneacetoacetic acid ethyl ester and 75 mmols of β-aminocrotonic acid 2-chlorobenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-ethoxycarbonyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-5-carboxylic acid 2-chlorobenzyl ester of melting point 120° C (from ethanol).

Sources & evidence

ORD record
ord-e2097ec881564de9b18c8a6d39644168
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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