HCID 68122246, compound → HCID 86735027, compound

HRID 442183Notes

Reaction equation

HRID 442183 reaction equation
[C:1]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][O:10][C:11]([C:13]2C(C3C=CC=C([N+]([O-])=O)C=3)C(C(OC)=O)=C(C)[NH:17][C:18]=2[CH3:19])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C>[C:1]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][O:10][C:11](=[O:12])/[CH:13]=[C:18](\[NH2:17])/[CH3:19])=[CH:7][CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 68122246HCID 68122246, compound

Product 1

HCID 86735027HCID 86735027, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 4-tert.-butylbenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-tert.-butylbenzyl ester of melting point 161° C (from ethanol).

Sources & evidence

ORD record
ord-476d4d3afb62417bbdebefe1cb151086
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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