HCID 68121419, compound → HCID 13673470, compound

HRID 442189Notes

Reaction equation

HRID 442189 reaction equation
COC1C=C(C=C(OC)C=1OC)[CH2:6][O:7][C:8](=[O:13])/[CH:9]=C(\N)/C.COC1C=C(C=C(OC)C=1OC)COC(C1[CH:31]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=2[N+:48]([O-:50])=[O:49])[C:32]([C:38]([O:40]C)=O)=C(C)NC=1C)=O>C(O)C>[CH3:6][O:7][C:8]([CH2:9][C:38](/[CH:32]=[CH:31]/[C:42]1[C:43]([N+:48]([O-:50])=[O:49])=[CH:44][CH:45]=[CH:46][CH:47]=1)=[O:40])=[O:13]

Participants

4

Reactant 2

HCID 68121419HCID 68121419, compoundHCID 86735029HCID 86735029, compound

Product 1

HCID 13673470HCID 13673470, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 ml of β-aminocrotonic acid 3,4,5-trimethoxybenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4,5-trimethoxybenzyl ester of melting point 125° C (from ethanol).

Sources & evidence

ORD record
ord-3f7edd0327664f43957705b9a5f501ef
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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