HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-aMino-2-naphthaMide | HCID 12471477 | — |
| Product | Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate | HCID 135961510 | 79% |
Reaction Steps
Diethyl oxalate (2.35 g., 16.1 millimoles), sodium methoxide (10 mg) and 2-aminonaphthalene-3-carboxamide (1.50 g., 8.05 millimoles) are mixed together and heated at reflux for two days. The mixture is then cooled in an ice bath and the brown precipitate recovered by filtration. It is recrystallized from ethanol to give 1.76 g. (79% yield) of the desired ester. M.P. 240°-242° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04044134 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-d287f2122eb64eb7a2dc12855beccfa1 |
| Source note | uspto-grants-1977_08 |