反应详情

Diethyl oxalate (2.35 g., 16.1 millimoles), sodium methoxide (10 mg) and 2-aminonaphthalene-3-carboxamide (1.50 g., 8.05 millimoles) are mixed together and heated at reflux for two days. The mixture is then cooled in an ice bath and the brown precipitate recovered by filtration. It is recrystallized from ethanol to give 1.76 g. (79% yield) of the desired ester. M.P. 240°-242° C.

1. temperatureheated
2. temperatureat reflux for two days
3. temperatureThe mixture is then cooled in an ice bath
4. filtrationthe brown precipitate recovered by filtration
5. customIt is recrystallized from ethanol
6. customto give 1.76 g