反应详情

A mixture of 2 g. of 3-allyl-5-(4'-fluorophenyl)2-hydroxy-benzoic acid, 5 g. of potassium hydroxide pellets and 2 ml. of water was heated under nitrogen in an oil bath at 170° C. for 1 hour with occasional stirring. The reaction mixture was cooled, dissolved in water, and the solution acidified. The product was extracted into ether. After drying the ether solution, and removing the ether, the product was recrystallized from benzene to yield 1.37 g., m.p. 196° -200° C. One more recrystallization from benzene raised the m.p. to 198° -201° C.

1. additionA mixture of 2 g
2. temperatureThe reaction mixture was cooled
3. extractionThe product was extracted into ether
4. dry with materialAfter drying the ether solution
5. customremoving the ether
6. customthe product was recrystallized from benzene
7. customto yield 1.37 g
8. customOne more recrystallization from benzene
9. temperatureraised the m.p. to 198° -201° C.