Thionyl Chloride → p-Azidomethylphenylacetyl chloride

HRID 442353Notes

Reaction equation

HRID 442353 reaction equation
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)=[N+:2]=[N-:3].S(Cl)([Cl:17])=O>>[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([Cl:17])=[O:14])=[CH:7][CH:6]=1)=[N+:2]=[N-:3]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 14197001p-Azidomethylphenylacetic acid

Product 1

HCID 20505454p-Azidomethylphenylacetyl chloride

Procedure

By stirring a mixture of the thus obtained p-azidomethylphenylacetic acid in thionyl chloride at room temperature for 20 hours the corresponding acid chloride is obtained after removal of the excess reagent under high vacuum at room temperature.

Workup

  1. customis obtained
  2. customafter removal of the excess reagent under high vacuum at room temperature

Sources & evidence

ORD record
ord-f49c209c3fbf49189a510222339b4fa7
Source dataset
uspto-grants-1977_08
Patent number
US04045438

Reaction notes

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