1-Chloro-2-nitrobenzene → HCID 21414420, compound

Participants

Reaction Steps

By analogous procedures as in Examples 6 and 10, using the corresponding starting materials, 2-amino-5-fluorophenyl 1-methyl-4-piperidyl ketone is prepared and reacted with o-chloronitrobenzene to give 5-fluoro-2-(o-nitroanilino)-phenyl 1-methyl-4-piperidyl ketone. This intermediate is then reduced and cyclized in the presence of an acidic catalyst to give 2-fluoro-11-(1-methyl-4-piperidyl)-5H-dibenzo-[b,e][1,4]diazepine.

Provenance & Evidence