反应详情

To a solution of morpholine (22 mmoles) in acetic acid (10 ml) there is added pyrrole (20 mmoles) dropwise at 0° C. Formaldehyde (37% aq., 20 mmoles) is then added dropwise. The reaction mixture is stirred for 2 hours at ambient temperature. The solution is cooled to 0° C. and is brought to alkaline pH (10-11) using 20% aqueous NaOH solution. After extraction with DCM, the organic phases are washed with water and with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product in the form of a white solid which is used directly in the next Step.

1. temperatureThe solution is cooled to 0° C.
2. extractionAfter extraction with DCM
3. washthe organic phases are washed with water and with saturated aqueous NaCl solution
4. dry with materialdried over sodium sulphate
5. filtrationfiltered
6. customevaporated to dryness