反应详情

温度

80 °C

A mixture of 9-(2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene (200 mg), formic acid (600 mg) and 37% formalin (0.25 ml) was stirred at 80° C for 2 hours. 4N Hydrochloric acid was added to the cooled reaction mixture, and the reaction mixture was evaporated to dryness. The residue was diluted with water, basified with aqueous ammonia and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-(4-methyl-2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene, M.P. 136° - 137° C.

1. customthe reaction mixture was evaporated to dryness
2. additionThe residue was diluted with water
3. extractionextracted with ethyl acetate
4. washThe ethyl acetate layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated to dryness