反应详情

A stirred suspension of 7.0 g. (0.0248 mole) of 4-benzoyl-3-methylthioindolin-2-one in 400 ml. of tetrahydrofuran was treated portionwise under a nitrogen atmosphere with 35.0 g. of Raney nickel over a 2.5 hr. period. The reaction mixture was stirred for 1.5 hr. after addition was complete and the catalyst removed by filtration. The filter cake was washed well with tetrahydrofuran and methylene chloride and the filtrate evaporated under reduced pressure. The residue (5.6 g.) was recrystallized from methanol and gave 4.45 g. (76%) of product m.p. 210°-212° C.

1. additionA stirred suspension of 7.0 g
2. additionafter addition
3. customthe catalyst removed by filtration
4. washThe filter cake was washed well with tetrahydrofuran and methylene chloride
5. customthe filtrate evaporated under reduced pressure
6. customThe residue (5.6 g.) was recrystallized from methanol
7. customgave 4.45 g