反应详情

A mixture of 1.0 g. (0.004 mole) of 5-benzoylindolin-2-one and 30 ml. of 3N sodium hydroxide was refluxed for 0.5 hour. The reaction mixture was cooled, acidified to pH 6 with 3N hydrochloric acid and slightly acidic solution was extracted with chloroform. The chloroform extracts were dried (magnesium sulfate) and concentrated to a solid. Recrystallization from ethanol-water gave 0.9 g. (84.5%) of pure product which melted at 143°-145° C.

1. additionA mixture of 1.0 g
2. temperatureThe reaction mixture was cooled
3. extractionwas extracted with chloroform
4. dry with materialThe chloroform extracts were dried (magnesium sulfate)
5. concentrationconcentrated to a solid
6. customRecrystallization from ethanol-water
7. customgave 0.9 g