HCID 54203958, compound → HCID 53758858, compound

HRID 442568Notes

Reaction equation

HRID 442568 reaction equation
[Br:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH2:12][O:13][CH:14]([OH:18])[CH2:15][CH2:16][OH:17])[CH:3]=1.[NH2:19]C1C2C(Cl)=CN(COC(O)CCO)C=2N=CN=1>>[NH2:19][C:9]1[C:10]2[C:2]([Br:1])=[CH:3][N:4]([CH2:12][O:13][CH:14]([OH:18])[CH2:15][CH2:16][OH:17])[C:5]=2[N:6]=[CH:7][N:8]=1

Participants

3

Reactant 2

HCID 54203958HCID 54203958, compoundHCID 54310262HCID 54310262, compound

Product 1

HCID 53758858HCID 53758858, compound

Procedure

Compound 22b was prepared from 5-bromo4-chloro-7-[(1,3-dihydroxypropoxy)methyl]pyrrolo[2,3-d]pyrimidine by the method described for 22a to yield 0.27 g (20%). mp=170°-172° C. 1H NMR (DMSO-d6): δ3.15-3.50 (m, 5); 4.59 (t, 2, exchanges with D2O, OH); 5.57 (s, 2, C-1'), 6.80 (bs, 2, exchanges with D2O, NH2); 7.53 (s, 1, C-6); 8.11 (s, 1, C-2). Anal. Calcd. for C10H13N4O3Br. (C,H,N).

Workup

  1. customto yield 0.27 g (20%)

Sources & evidence

ORD record
ord-1169ad79ceb94d18a9e56048ce57aa11
Source dataset
uspto-grants-1999_04
Patent number
USRE036187

Reaction notes

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