HCID 54310262, compound → HCID 54057494, compound

HRID 442569Notes

Reaction equation

HRID 442569 reaction equation
Cl[C:2]1[C:3]2[C:10]([I:11])=[CH:9][N:8]([CH2:12][O:13][CH:14]([OH:18])[CH2:15][CH2:16][OH:17])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:19]C1C2C(Cl)=CN(COC(O)CCO)C=2N=CN=1>>[NH2:19][C:2]1[C:3]2[C:10]([I:11])=[CH:9][N:8]([CH2:12][O:13][CH:14]([OH:18])[CH2:15][CH2:16][OH:17])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 54310262HCID 54310262, compoundHCID 54461711HCID 54461711, compound

Product 1

HCID 54057494HCID 54057494, compound

Procedure

Compound 22c was prepared from 4-chloro-5-iodo-7-[(1,3-dihydroxypropoxy)methyl]pyrrolo[2,3-d]pyrimidine by the method described for 22a to yield 0.20 g (51%). mp=177°-177.5° C. 1H NMR (DMSO-d6): δ3.22-3.52 (m, 5); 4.58 (t, 2, exchanges with D2O, OH); 5.57 (s, 2, C-1'); 6.66 (bs, 2, exchanges with D2O, NH2); 7.55 (s, 1, C-6); 8.11 (s, 1, C-2). Anal. for C10H13N4O3I. (C,H,N).

Workup

  1. customto yield 0.20 g (51%)

Sources & evidence

ORD record
ord-0fd41626a1004d7a839e07792665e060
Source dataset
uspto-grants-1999_04
Patent number
USRE036187

Reaction notes

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