反应详情

A mixture of compound 8 (10.40 g, 0.04 mol), sodium hydroxide (11.67 g, 0.208 mol), water (23 ml) and ethanol (225 ml) was heated under reflux for 2 h. The solution was allowed to cool, to room temperature, and then acidified with dilute hydrochloric acid. The solvent was removed to leave a white solid which was dissolved in ether and washed successively with saturated sodium hydrogen carbonate solution (until no more effervescense was observed) and water. After drying the ether (MgSO4), the solvent was removed in vacuo and the white solid was recrystallised from ethanol to yield colourless crystals.

1. temperaturewas heated
2. temperatureunder reflux for 2 h
3. customThe solvent was removed
4. customto leave a white solid which
5. washwashed successively with saturated sodium hydrogen carbonate solution (until no more effervescense
6. dry with materialAfter drying the ether (MgSO4)
7. customthe solvent was removed in vacuo
8. customthe white solid was recrystallised from ethanol
9. customto yield colourless crystals