反应详情

To a solution of the product obtained in Step F (7.45 g) in MeOH (1.5 L) there are added 223 ml of a 1.4N solution of NH3 in MeOH and PtO2 (5.2 g). The reaction mixture is placed under an atmosphere of hydrogen and is then stirred for 20 hours at ambient temperature. After filtration and evaporation to dryness, the residue obtained is purified on silica gel (SiO2: gradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH) to yield the title product which is used directly in the next Step.

1. filtrationAfter filtration and evaporation to dryness
2. customthe residue obtained
3. customis purified on silica gel (SiO2
4. additiongradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH)