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HRID442622

反应详情

EQUATION

反应方程式

HRID 442622 的结构方程式

REACTANTS

反应物

2
结构：Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)OCCO)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2
HCID71406

未命名化合物

3 次

结构：C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
HCID5284373

Cyclosporin A

C62H111N11O12

3 次

PRODUCTS

生成物

1
结构：C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C.Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)OCCO)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2
HCID131721213

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

200 mg of Cyclosporine was weighed into a 100 ml beaker and 1.2 grams of Vitamin E TPGS was added, and to this was added 8 grams of ethanol. The ethanol solvent, Cyclosporine, and TPGS were stirred at room temperature for 10 minutes until the Cyclosporine and TPGS components were clearly dissolved. The solvent was evaporated from a Petri dish overnight and the sample was examined under an Olympus BX50 microscope at 200× magnification by adding a small quantity of water to the cyclosporine/TPGS, and watching for visible crystals. No crystals were observed, only a clear solution was obtained. It was therefore concluded that solvent evaporation will also work to produce clear solutions of Cyclosporine/TPGS when added to water.

WORKUP

后处理

  1. additionwas added
  2. dissolutionwere clearly dissolved
  3. customThe solvent was evaporated from a Petri dish overnight
  4. additionby adding a small quantity of water to the cyclosporine/TPGS
  5. customonly a clear solution was obtained
  6. customIt was therefore concluded that solvent evaporation