HCID 66636497, compound → 4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

HRID 44264Notes

Reaction equation

HRID 44264 reaction equation
[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH2:13][OH:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>C1COCC1.O=[Mn]=O>[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH:13]=[O:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 66636497HCID 66636497, compound

Product 1

HCID 866508254-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the product obtained in Step I (0.09 g) in THF (3.8 ml) there is added activated MnO2 (0.315 g). After stirring for 20 hours at ambient temperature, the mixture is filtered and the filtrate is evaporated to dryness to yield the title product, which is used directly in the next step.

Workup

  1. filtrationthe mixture is filtered
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-149fe9fcd74f4f9198e7139940144834
Source dataset
uspto-grants-2013_09
Patent number
US08541412B2

Reaction notes

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