Acetic Acid → HCID 10780390, compound

HRID 442666Notes

Reaction equation

HRID 442666 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([C:8]2[CH:13]=[C:12]3[O:14][CH2:15][O:16][C:11]3=[CH:10][C:9]=2[CH2:17][C:18](OC)=[O:19])=O)=[CH:4][CH:3]=1.O.[NH2:25][NH2:26].C(O)(=O)C.O>C(O)C>[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[C:8]3[CH:13]=[C:12]4[O:14][CH2:15][O:16][C:11]4=[CH:10][C:9]=3[CH2:17][C:18](=[O:19])[NH:26][N:25]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 406957HCID 406957, compound

Product 1

HCID 10780390HCID 10780390, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from methyl 2-(4-fluorobenzoyl)-4,5-methylenedioxyphenylacetate (350 mg, 1.11 mmol), hydrazine hydrate (180 μL, 3.18 mmol), and acetic acid (50 μL) in ethanol (10 mL), mp: 205°-207° C. 1H NMR (CDCl3) 8.45 (s, 1H), 7.59 (dd, 2H, J=8.5, J=5.5), 7.11 (dd, 2H, J=8.5, J=8.5), 6.83 (s, 1H), 6.61 (s, 1H), 6.04 (s, 2H), 3.45 (s, 2H). Anal. calcd. for C16H11FN2O3.0.125 H2O: C, 63.94; H, 3.77; N, 9.32. Found: C, 63.83; H, 3.58; N, 9.03.

Sources & evidence

ORD record
ord-193bf0965b18484da8c1c093c3f4b75c
Source dataset
uspto-grants-1999_04
Patent number
US05891871

Reaction notes

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