HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-nitrobenzoic acid → Methyl 2-(2-Chloro-4-nitrobenzoyl)-4,5-methylenedioxyphenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-nitrobenzoic acid | HCID 7448 | — |
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Reactant | Methyl 2-(1,3-dioxaindan-5-yl)acetate | HCID 266588 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | Methyl 2-(2-Chloro-4-nitrobenzoyl)-4,5-methylenedioxyphenylacetate | HCID 54561972 | — |
Reaction Steps
The title compound was prepared from methyl 3,4-methylenedioxyphenylacetate (12.5 g, 64.4 mmol) in ClCH2CH2Cl (150 mL), 2-chloro-4-nitrobenzoic acid (25.0 g, 124 mmol) and P2O5 (37 g) as a yellow solid (11 g, 29 mmol, 45%). 1H NMR (CDCl3) 8.15 (s, 1H), 8.14 (d, J=8.4, 1H), 7.58 (d, J=8.4, 1H), 6.84 (s, 1H), 6.71 (s, 1H), 6.05 (s, 2H), 4.03 (s, 2H), 3.73 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891871 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-6d8cb946cb9747c18dbcd3ca89bd3c5c |
| Source note | uspto-grants-1999_04 |