反应详情

In 10 ml of dry acetonitrile were dissolved 478 mg of nitronium tetrafluoroboron (85% content), 0.43 ml of 2,4,6-collidine was added thereto with stirring under ice-cooling, and the mixture was stirred under ice-cooling for 30 minutes. To the resulting mixture were added 500 mg of (4R)-N-[(1S)-1-methyl-2-hydroxyethyl]-2-oxothiazolidin-4-yl-carboxamide, and the mixture was stirred at room temperature for 1 hour and 45 minutes. Then, the solvent was distilled off under reduced pressure and the thus obtained residue was purified by silica gel column chromatography employing cyclohexane-ethyl acetate (3:7) as an eluent to obtain 178 mg of the desired compound as colorless crystals.

1. additionwas added
2. temperaturecooling
3. stirringthe mixture was stirred under ice-
4. temperaturecooling for 30 minutes
5. stirringthe mixture was stirred at room temperature for 1 hour and 45 minutes
6. distillationThen, the solvent was distilled off under reduced pressure
7. customthe thus obtained residue was purified by silica gel column chromatography