反应详情

The product from Example 27A (0.865 g, 5.0 mmol) was dissolved in THF (10 mL) and 0.27 g NaOMe was added. After 3 h and 25° C., the reaction was quenched in 5% aq. NaHCO3 solution and extracted with diethyl ether. The organic phase was dried, evaporated, and the residue purified by column chromatography, eluting with 70:30 hexanes:ethyl acetate to yield 0.27 g (32%, second eluting component) of the title compound: 1H NMR (300 MHz, CDCl3) δ 3.95 (s, 3H), 7.29 (d, 1H), 8.28 (d, 1H).

1. custom25° C., the reaction was quenched in 5% aq. NaHCO3 solution
2. extractionextracted with diethyl ether
3. customThe organic phase was dried
4. customevaporated
5. customthe residue purified by column chromatography
6. washeluting with 70:30 hexanes