反应详情

Following the procedure described in Example (v) using 4-[2-(9H-thioxanthen-9-yl)acetyl]benzonitrile (3 g, 8.8 mmol), ammonium carbonate (3.1 g, 3.2 mmol) and potassium cyanide (1.03 g, 5.8 mmol) in ethanol-water (1:1, 15 ml) gave after work up a yellow solid. This was purified on flash silica eluting with dichloromethane and then ethyl acetate. The ethyl acetate fractions were combined and evaporated to a solid which was triturated with dichloromethane to give 5-(4-cyanophenyl)-5-(9H-thioxanthen-9-ylmethyl) hydantoin as a yellow solid.

1. customgave after work up a yellow solid
2. customThis was purified on flash silica eluting with dichloromethane
3. customevaporated to a solid which
4. customwas triturated with dichloromethane