反应详情

Boron trifluoride-ether complex (0.36 ml, 2.94 mmol) was added dropwise at 0° C. to a solution of 4,4'-bis(methoxymethoxy)benzhydrol (8.96 g, 29.43 mmol) and 1-(2-chlorophenyl)-4-(indol-2-ylcarbonyl)piperazine (10.0 g, 29.43 mmol) in 200 ml of methylene chloride, followed by stirring at 0° C. to room temperature for 2 hours. A saturated aqueous solution of sodium bicarbonate was added to the reaction solution for neutralization followed by extraction with chloroform. The resulting organic layer was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to give a crude product. The obtained crude product was recrystallized from ethanol to, give 15.1 g (yield: 82%) of the title compound.

1. extractionfollowed by extraction with chloroform
2. washThe resulting organic layer was washed with a saturated aqueous solution of sodium bicarbonate
3. dry with materiala saturated aqueous solution of sodium chloride, and dried over magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure
5. customto give a crude product
6. customThe obtained crude product
7. customwas recrystallized from ethanol to,