HRID442854

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11636816

N,N-Dimethylaminoethyl chloride hydrochloride

C4H11Cl2N

结构：COc1ccc(C(c2ccc(OC)cc2)c2c(C(=O)N3CCN(c4ccccc4Cl)CC3)[nH]c3ccccc23)cc1

HCID70147134

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(c2ccc(OC)cc2)c2c(C(=O)N3CCN(c4ccccc4Cl)CC3)n(CCN(C)C)c3ccccc23)cc1

HCID70146628

未命名化合物

收率 67%

PROCEDURE

实验过程

Substantially the same procedure as in Example 2 was repeated using Compound 29 (1.0 g, 1.77 mmol) obtained in Example 29 and 2-dimethylaminoethylchloride hydrochloride (266 mg, 1.85 mmol) to give 0.75 g (yield: 67%) of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-137ed8bf79a24c52a6028ab875756ee0
来源数据集: uspto-grants-1999_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05891902
来源说明: uspto-grants-1999_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)[C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12][C:11]=2[C:19]([N:21]2[CH2:26][CH2:25][N:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[Cl:33])[CH2:23][CH2:22]2)=[O:20])=[CH:5][CH:4]=1.Cl.[CH3:43][N:44]([CH3:48])[CH2:45][CH2:46]Cl>>[CH3:41][O:40][C:37]1[CH:36]=[CH:35][C:34]([CH:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH2:46][CH2:45][N:44]([CH3:48])[CH3:43])[C:11]=2[C:19]([N:21]2[CH2:22][CH2:23][N:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[Cl:33])[CH2:25][CH2:26]2)=[O:20])=[CH:39][CH:38]=1