HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaminoethyl chloride hydrochloride → 1-{3-[Bis(4-methoxyphenyl)methyl]-1-(2-dimethylaminoethyl)indol-2-ylcarbonyl}-4-(2-chlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | HCID 70147134 | HCID 70147134 | — |
| Product | 1-{3-[Bis(4-methoxyphenyl)methyl]-1-(2-dimethylaminoethyl)indol-2-ylcarbonyl}-4-(2-chlorophenyl)piperazine | HCID 70146628 | 67% |
Reaction Steps
Substantially the same procedure as in Example 2 was repeated using Compound 29 (1.0 g, 1.77 mmol) obtained in Example 29 and 2-dimethylaminoethylchloride hydrochloride (266 mg, 1.85 mmol) to give 0.75 g (yield: 67%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891902 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-137ed8bf79a24c52a6028ab875756ee0 |
| Source note | uspto-grants-1999_04 |