Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 3-{Bis [4-(methoxymethoxy)phenyl]methyl}-2-[4-(2-chlorophenyl)piperazinylsulfonyl]-1-(2-morpholinoethyl)-indole

HRID 442867Notes

Reaction equation

HRID 442867 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:37]2[CH:42]=[CH:41][C:40]([O:43][CH2:44][O:45][CH3:46])=[CH:39][CH:38]=2)[C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][C:13]=2[S:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[Cl:36])[CH2:26][CH2:25]2)(=[O:23])=[O:22])=[CH:7][CH:6]=1.Cl.[O:48]1[CH2:53][CH2:52][N:51]([CH2:54][CH2:55]Cl)[CH2:50][CH2:49]1>>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:37]2[CH:38]=[CH:39][C:40]([O:43][CH2:44][O:45][CH3:46])=[CH:41][CH:42]=2)[C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:55][CH2:54][N:51]3[CH2:52][CH2:53][O:48][CH2:49][CH2:50]3)[C:13]=2[S:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[Cl:36])[CH2:26][CH2:25]2)(=[O:22])=[O:23])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 676918923-(Bis[4-(methoxymethoxy)phenyl]methyl)-2-[4-(2-chlorophenyl)piperazinylsulfonyl]indole

Product 1

HCID 676920513-{Bis [4-(methoxymethoxy)phenyl]methyl}-2-[4-(2-chlorophenyl)piperazinylsulfonyl]-1-(2-morpholinoethyl)-indole

Procedure

Substantially the same procedure as in Example 243 was repeated using Compound 241 (1.1 g, 1.66 mmol) obtained in Example 242 and 2-morpholinoethylchloride hydrochloride (310 mg, 1.66 mmol) to give 1.3 g (quantitative) of the title compound.

Sources & evidence

ORD record
ord-cd627e012bb544b68352bc59e5d1417d
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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