Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 3-{Bis [4-(methoxymethoxy)phenyl]methyl}-2-[4-(2-chlorophenyl)piperazinylsulfonyl]-1-(2-morpholinoethyl)-indole

Participants

Role	Name	HCID	Charge
Reactant	Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)	HCID 77210	—
Reactant	3-(Bis[4-(methoxymethoxy)phenyl]methyl)-2-[4-(2-chlorophenyl)piperazinylsulfonyl]indole	HCID 67691892	—
Product	3-{Bis [4-(methoxymethoxy)phenyl]methyl}-2-[4-(2-chlorophenyl)piperazinylsulfonyl]-1-(2-morpholinoethyl)-indole	HCID 67692051	—

Reaction Steps

Substantially the same procedure as in Example 243 was repeated using Compound 241 (1.1 g, 1.66 mmol) obtained in Example 242 and 2-morpholinoethylchloride hydrochloride (310 mg, 1.66 mmol) to give 1.3 g (quantitative) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05891902
Source dataset	uspto-grants-1999_04
ORD ID	ord-cd627e012bb544b68352bc59e5d1417d
Source note	uspto-grants-1999_04