Ethyl indole-2-carboxylate → Ethyl 3-{bis[4-(methoxymethoxy)phenyl]methyl}-indole-2-carboxylate

HRID 442877Notes

Reaction equation

HRID 442877 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:22]=[CH:21][C:8]([CH:9](O)[C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][O:18][CH3:19])=[CH:12][CH:11]=2)=[CH:7][CH:6]=1.[NH:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[C:24]1[C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:22]=[CH:21][C:8]([CH:9]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][O:18][CH3:19])=[CH:12][CH:11]=2)[C:25]2[C:26]3[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=3)[NH:23][C:24]=2[C:32]([O:34][CH2:35][CH3:36])=[O:33])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 54082355HCID 54082355, compound

Product 1

HCID 70146597Ethyl 3-{bis[4-(methoxymethoxy)phenyl]methyl}-indole-2-carboxylateYield 89%

Procedure

Substantially the same procedure as in Example 1 was repeated using 4,4'-bis(methoxymethoxy)benzhydrol (6.22 g, 32.9 mmol) and ethyl indole-2-carboxylate (10.0 g, 32.9 mmol) to give 12.9 g (yield: 89%) of the title compound.

Sources & evidence

ORD record
ord-96fe846d8fbf4eaf9011378fe735e103
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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