反应详情

Boron trifluoride-ether complex (0.65 ml, 5.29 mmol) was added to a solution of ethyl indole-2-carboxylate (10.0 g, 52.9 mmol) in 100 ml of methylene chloride, and a solution of benzhydryl acetate (11.4 g, 50.2 mmol) in 50 ml of methylene chloride was dropwise added thereto, followed by stirring at room temperature for 40 minutes. A saturated aqueous solution of sodium bicarbonate was added to the reaction solution for neutralization followed by extraction with chloroform. The resulting organic layer was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to give a crude product. The obtained crude product was washed with diisopropyl ether to give 15.8 g (yield: 84%) of the title compound.

1. extractionfollowed by extraction with chloroform
2. washThe resulting organic layer was washed with a saturated aqueous solution of sodium bicarbonate
3. dry with materiala saturated aqueous solution of sodium chloride, and dried over magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure
5. customto give a crude product
6. customThe obtained crude product
7. washwas washed with diisopropyl ether